NFL odds, Vegas lines, picks, spreads, bets, predictions for Week 5, 2021: Model loving Patriots, Packers


The 2021 NFL schedule has already supplied plenty of memorable moments, and bettors who took a chance by backing the Giants and Jets last week were rewarded with both New York teams winning outright as underdogs. Now, the Jets will face the Falcons in London, while the Giants will play the Cowboys, and both are underdogs in the NFL odds. The Falcons are 2.5-point favorites in the latest Week 5 NFL spreads from Caesars Sportsbook, while the Cowboys are seven-point favorites.

Elsewhere in the Week 5 NFL Vegas odds, the Buccaneers are the largest favorites of the week, laying 10 points to the Dolphins. Tampa Bay needed a missed Nick Folk field goal as time expired to hold on against the Patriots and are now 1-3 against the spread, so should you include them among your Week 5 NFL bets? All of the NFL lines are listed below, and before making any Week 5 NFL picks on these games or others, be sure to see the Week 5 NFL predictions from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 5 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 5 NFL predictions

One of the top Week 5 NFL predictions the model recommends: The Patriots (-8) cover the spread against the Texans in almost 60 percent of simulations. Both teams are coming off losses but looked drastically different while getting them. New England hung with the Super Bowl champs until the very end, while Houston suffered its most lopsided defeat in franchise history, falling 40-0 to Buffalo.

The Texans have nothing to hang their hats on entering Week 5 and rank among the bottom five in points scored, yards gained, points allowed and yards allowed. Rookie quarterback Davis Mills threw four interceptions last week and now faces a Patriots defense that has historically dominated rookie quarterbacks. That includes the Jets’ Zach Wilson, who threw four picks and was sacked four times versus New England in Week 2.

Another one of its Week 5 NFL predictions: The Packers (-3) cover on the road against the Bengals in a matchup of 3-1 teams. Both teams are 3-1 on the season and have hit speed bumps on the way to those matching records.

The Packers were blown out by the Saints in Week 1, but rebounded to beat the Lions, 49ers and Steelers. The Bengals needed a last-second field goal to beat the Vikings, lost 20-17 to the Bears, handled the Steelers and barely snuck past the Jaguars.

Packers quarterback Aaron Rodgers has thrown for 763 yards with eight touchdowns and no interceptions since his poor opening-week performance, and the Packers have forced six turnovers in the last three weeks. The model predicts that Green Bay wins the turnover battle to help the Packers cover in over 50 percent of simulations.

How to make Week 5 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 5 NFL schedule, and it’s calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $7,900 since its inception, and find out.

Week 5 NFL odds, spreads, lines

Sunday, Oct. 10

Jets at Falcons (-2.5, 45)

Featured Game | Atlanta Falcons vs. New York Jets

Dolphins at Buccaneers (-10, 48)

Featured Game | Tampa Bay Buccaneers vs. Miami Dolphins

Eagles at Panthers (-3, 46)

Featured Game | Carolina Panthers vs. Philadelphia Eagles

Saints at Washington (+2.5, 43.5)

Featured Game | Washington Football Team vs. New Orleans Saints

Titans at Jaguars (+4.5, 48.5)

Featured Game | Jacksonville Jaguars vs. Tennessee Titans

Lions at Vikings (-10, 49.5)

Featured Game | Minnesota Vikings vs. Detroit Lions

Broncos at Steelers (+1.5, 39.5)

Featured Game | Pittsburgh Steelers vs. Denver Broncos

Packers at Bengals (+3, 50.5)

Featured Game | Cincinnati Bengals vs. Green Bay Packers

Patriots at Texans (+8, 39)

Featured Game | Houston Texans vs. New England Patriots

Bears at Raiders (-5.5, 45)

Featured Game | Las Vegas Raiders vs. Chicago Bears

Browns at Chargers (-2.5, 47)

Featured Game | Los Angeles Chargers vs. Cleveland Browns

Giants at Cowboys (-7, 52)

Featured Game | Dallas Cowboys vs. New York Giants

49ers at Cardinals (-5, 48.5)

Featured Game | Arizona Cardinals vs. San Francisco 49ers

Bills at Chiefs (-3, 56.5)

Featured Game | Kansas City Chiefs vs. Buffalo Bills

Monday, Oct. 11

Colts at Ravens (-7, 46)

Featured Game | Baltimore Ravens vs. Indianapolis Colts

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